For additional information about products that might contain Propylene glycol, visit the Household Products Database online at the United States National Library of Medicine. Positive patch test reactions to propylene glycol are difficult to interpret.. Also, if a food lists "natural flavors", "natural flavoring", "artificial flavor", or "artificial flavoring", the flavoring can contain propylene glycol that would not be separately listed as an ingredient - in foods with these ingredients listed there is no way to find out for certain if the the food contains propylene glycol or not. Patch Testing to Propylene Glycol: The Mayo Clinic Experience. Amongst other things, it is used as a humectant, solvent, emulsifier, penetration enhancer and emollient, a food additive, and an intermediate in manufacturing polyester. EPA Pesticide Chemical Code 068603 As a pharmaceutical additive, propylene glycol is generally regarded as safe. Survivorship-Reducing Effect of Propylene Glycol on Vector Mosquito Populations and Its Potential Use in Attractive Toxic Sugar Baits. PMC Dermatitis. industrial fluids, such as solvents, thinners, antifreeze, other de-icing fluids, Propylene glycol is a widely used emollient and emulsifier with well-established irritant and allergic potential. Epub 2021 Sep 23. It may be accompanied by a burning, stinging sensation. Propylene glycol is also found in air fresheners, such as Glade Premium Room Sprays. Epub 2015 Sep 4. The patient's condition cleared after discontinuation of all topical products containing PG and her other identified allergens, but she noted flares of her contact dermatitis following the ingestion of foods containing PG. Finally, some beers may contain propylene glycol and beers do not have to list it as an ingredient. Allergic contact dermatitis to propylene glycol via occupational exposureis less common, but has been reported in the mechanical and motor vehicle, and printing industries. Contact allergy to propylene glycol, Authors: Libby Schurr, Trainee Medical Intern, The University of Auckland; Dr Harriet Cheng, Consultant Dermatologist, ADHB, New Zealand. Dermatitis. PMC My skin problems, however, go back to June 2013 when I was misdiagnosed with "postmenopausal atrophic vaginitis". Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Epub 2018 Nov 1. Epub 2021 Mar 15. Containing two alcohol groups, it is classed as a diol. This response leads to symptoms like a sore throat, itchy hives, face/tongue numbness, nausea, headaches and sinus problems. Contact Dermatitis, 73, 6, (376-377), . arrow-right-small-blue Clipboard, Search History, and several other advanced features are temporarily unavailable. Approach to allergic contact dermatitis caused by topical medicaments. Intolerance to cosmetics as key to the diagnosis in a patient with allergic contact dermatitis caused by propylene glycol contained in a topical medication. P ropylene glycol (PG) (propane1,2diol) is widely used in pharmaceutic manufacturing as a solvent and vehicle, especially for drugs unstable or insoluble in water. 2018 Jun;120(6):599-602. doi: 10.1016/j.anai.2018.04.017. Before Pediatr Dermatol. Federal government websites often end in .gov or .mil. Copy edited by Gus Mitchell. Pediatr Dermatol. doi:10.1097/DER.0000000000000307. Rarely, it may cause systemic contact dermatitis; for example, following ingestion of food or medication containing propylene glycol. Cutaneous reactions to PG are mostly irritant, but allergic contact dermatitis to PG is well-documented. . 8600 Rockville Pike and transmitted securely. Bethesda, MD 20894, Web Policies The site is secure. Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018. DermNet does not provide an online consultation service.If you have any concerns with your skin or its treatment, see a dermatologist for advice. May I ingest either? Disclaimer, National Library of Medicine At times it can be added to packaged or processed foods, especially any that are thick liquids, creams, icings, sauces, etc, but in those cases it will listed as an ingredient. This is characterised by a rash, possibly with small lumps in the surrounding area or even just a patch of redness. The https:// ensures that you are connecting to the Contact, systemic, and irritant cutaneous reactions have been documented for PG, which has become an increasingly common ingredient. Doctor's Assistant: The Pharmacist can help. Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. User allergic contact dermatitis story submitted on 2/23/16: "I was diagnosed with my propylene glycol (PG)/polyethylene glycol (PEG) allergy by patch testing in April 2014. See dermatitis for more information on treatment. Wiley Online Library . Propylene glycol allergy list suggests that you will see that the skin will feel itchy, burning, and irritation. The .gov means its official. "Propylene glycol is often the culprit." Polyethylene glycol is not a propylene glycol derivative, and is not a cross reactor. Alternative names for propylene glycol include: Propylene glycol was named the American Contact Dermatitis Societys Allergen of the Year for 2018. Please enable it to take advantage of the complete set of features! You may need to check with your pharmacist or doctor which topical and other medications will be suitable for you. Development of the red rash on the hairline and the neck is common. 8600 Rockville Pike 2003 Jun;48(6):345. doi: 10.1034/j.1600-0536.2003.00143.x. Crossref. Most commonly, these symptoms are a result of an allergic reaction to propylene glycol, or less commonly, to minoxidil itself. official website and that any information you provide is encrypted [1] Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018. It is an organic compound commonly found in topical corticosteroids (CS). Current strategies for managing irritant contact dermatitis due to transdermal patches include patch application site rotation, shorter application intervals, and pre-application of clobetasol. Before These lists are brief and provide just a few examples. Propylene glycol allergic contact dermatitis. government site. These rashes are not contagious or life-threatening, but can be very uncomfortable. Hernndez N, Hernndez Z, Liuti F, Borrego L. Contact Dermatitis. doi: 10.1111/pde.12668. Polyethylene glycols are condensation products of glycols with ethylene oxide. PMID: 12931739 No abstract available Publication types Disclaimer, National Library of Medicine Propylene glycol is the American Contact Dermatitis Society's Allergen of the Year for 2018. Propylene glycol is safe in small doses. Dall'Oglio F, Nasca MR, Gerbino C, Micali G. Clin Cosmet Investig Dermatol. Typical symptoms include redness, swelling, itching, and fluid-filled blisters. If you have an allergy to propylene glycol, you may also be allergic to other common contact allergens, such as balsam of Peru, fragrance mix, benzalkonium chloride (BAK), and/or other topical medicine components eg. Careers. Propylene glycol is used as a softening agent, preservative, humectants, and solvent in cosmetics, fragrances, topical medications, soaps and cleansers, hair care products, and deodorants. The site is secure. Propylene glycol allergic contact dermatitis. Does that mean I'm also allergic to polyethylene glycol? Skin reactions to propylene glycol are mostly irritant, but allergic contact dermatitis to propylene glycol has been well-documented. Cosensitization to PG and topical CS can occur, making it challenging to choose the appropriate topical CS in a PG-allergic patient. The most common side effect of topical minoxidil is irritant contact dermatitis with the typical symptoms of itching and scaling. Warshaw EM, Botto NC, Maibach HI, Fowler JF Jr, Rietschel RL, Zug KA, Belsito DV, Taylor JS, DeLeo VA, Pratt MD, Sasseville D, Storrs FJ, Marks JG Jr, Mathias CG. Epub 2018 Apr 24. PG is an infrequent cause of occupational dermatitis. It is used as stabilizer for vitamins, and as a water-miscible cosolvent. EINECS 200-338-0 Cigarettes may also be an underreported and. Contact dermatitis that results from PG can also be systemic if the patient ingests this chemical. They are not comprehensive. This is one of the first ingredients IN EVERYTHING - shampoo, the best foundations, cleansers, deodorant, toothpaste, even donuts. 2018 Jul/Aug;29(4):200-205. doi: 10.1097/DER.0000000000000393. Where is propylene glycol found? Marylin Desjardins and Fahad Almutawa, Allergic contact dermatitis caused by glycyrrhetinic acid and castor oil, Contact Dermatitis, 64, 3, (168-169), (2011). Read product labels carefully and talk to your doctor if you have any questions. It causes contact dermatitis and also systemic contact dermatitis, meaning if you have a skin allergy to propylene glycol, it may also cause a reaction if you inhale it or are exposed to it orally, in an injection, or through the mucosa (mouth . Cutaneous reactions to PG are mostly irritant, but allergic contact dermatitis to PG is well-documented. Although it is well suited for this purpose, it is capable of producing both primary irritant skin reaction and allergic sensitization. Disclaimer, National Library of Medicine This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Individuals sensitised to propylene glycol will develop dermatitis where there has been skin contact. Review of Allergic Contact Dermatitis ACD is an immunological reaction that occurs in genetically susceptible people who have been previously sensitized to an allergen. rations for patients with a history of allergic or irri-tant contact dermatitis to glycols. Propylene glycol ( IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. 2005 Nov;53(5):247-59. doi: 10.1111/j.0105-1873.2005.00693.x. Case 2. These are not cross-reactions. Jacob SE, Scheman A, McGowan MA. Allergic contact dermatitis from propylene glycol in Efudix cream. Allergic contact dermatitis from propylene glycol ricinoleate in a lipstick. Current strategies for managing irritant contact dermatitis due to transdermal patches include patch application site rotation, shorter application intervals, and pre-application of clobetasol. eCollection 2022. [Allergic contact dermatitis and systemic contact dermatitis in a patient with polysensitization to topical corticosteroids]. If you have a PG allergy, you'll likely show signs of allergic contact dermatitis. Copyright 2022 Contact Dermatitis Institute All Rights Reserved | Terms and Conditions | HIPAA Policy | Privacy, Data Subject Rights and Security Policy, Privacy, Data Subject Rights and Security Policy. It is a viscous, colourless, and odourless liquid with low toxicity. Tocci EM, Robinson A, Belazarian L, Foley E, Wiss K, Silvestri DL. Ingredients. Bethesda, MD 20894, Web Policies PG may cause contact dermatitis and local irritation of the skin and mucous membranes. It is an organic compound commonly found in topical corticosteroids (CS). Clinical review II I Propylene glycol dermatitis Joseph M. Catanzaro, MD, and J. Graham Smith, Jr., MD Augusta, Georgia Propylene glycol is a commonly used vehicle for topical preparations. Patch testing detailsAmerican Contact Dermatitis Core Series: 30% aqueous solutionNZ Extended Series: 5% petrolatum. HHS Vulnerability Disclosure, Help Actas Dermosifiliogr. Ann Allergy Asthma Immunol. Contact Dermatitis. What should I do to avoid propylene glycol? Contact allergy to propylene glycol codes and concepts. Signs you have a propylene glycol allergy Your skin will itch, burn, and feel tender Your scalp may feel dry, and flake You can develop a red rash on your hairline, ear, or neck Your skin will feel swollen The symptoms appear one to two days after you come in contact with the allergen Because PG is inhaled when you vape, this will be around your mouth and nose. Seeing a doctor is the best when you contact for dermatitis-based symptoms. Although uncommon, acute renal failure has been attributed to propylene glycol. This review serves to delve into what the authors know about PG from previous reports and studies so that providers will have a better understanding of PG contact dermatitis. Previous reported cases of allergic contact dermatitis due to pentylene glycol Due to the similar chemical structure between PTG and PG, differing only in a longer carbon chain and the position of alcohol groups in PTG, a cross-reaction could be expected. 2022 Aug 6;15:1537-1548. doi: 10.2147/CCID.S284671. 2015 Nov-Dec;32(6):e242-4. Propylene glycol is also found in oral treatments as well as many foods. arp torque specs Though it can be a bit tricky to avoid all Propylene-glycol products due to their wide range of usages like hair conditioners, shampoos, and deodorants patients with this . Propylene Glycol Allergic contact dermatitis is a T-cell dependent, delayed-type (Type IV) hypersensitivity reaction that has a high impact both in terms of patient morbidity and economics. Eczema complicated by allergic contact dermatitis to topical medications and excipients. Isopropylene glycol DermNet does not provide an online consultation service. This site needs JavaScript to work properly. Propylene glycol may produce eczematous skin reactions of toxic and, more rarely, of allergic nature. An Overview of the Diagnosis and Management of Seborrheic Dermatitis. Because, a dermatologist told colleagues, it's so common. January 2022. Turns out my face washes (cerave and a medicated acne one my dermatologist gave me for closed comedones along w . An official website of the United States government. The https:// ensures that you are connecting to the government site. It is a viscous, colourless, and odourless liquid with low toxicity. Epub 2015 Sep 4. DermNet provides Google Translate, a free machine translation service. I'm mostly concerned about the skincare stuff. What are the features of contact allergy to propylene glycol? How is contact allergy to propylene glycol treated? Careers. Propylene glycol is used as a softening agent, preservative, humectants, and 2018 Jan-Feb;29(1):3-5. doi: 10.1097/DER.0000000000000315. The https:// ensures that you are connecting to the Unable to load your collection due to an error, Unable to load your delegates due to an error. It is a common cause of allergic contact dermatitis (ACD) and was named the ACD Society's allergen of the year in 2018. To submit resources or links, please fill out the submission form at the top of this page. Propylene glycol is a widely used and increasingly common ingredient in a multitude of products. Research has suggested that individuals who have a sensitivity to propylene glycol may experience a special form of irritation known as allergic contact dermatitis. Propylene glycol is an organic compound that is formulated in many personal care products and pharmaceutical preparations. bacitracin or neomycin sulfate. care products, and deodorants. It may also be employed as a preservative, and is extensively used in foods and cosmetics ( 1 ). Propylene glycol is as contentious as it is ubiquitous because it acts as both a weak sensitizer and an irritant, confounding the results of positive patch tests. Among the patients we patch tested, propylene glycol was found to be the contactant in a majority of cases, not the minoxidil itself. 2022 Jun 29;13(7):595. doi: 10.3390/insects13070595. How is contact allergy to propylene glycol diagnosed? The site is secure. Contact allergy to topical glucocorticoids. We report a case of allergic contact . and transmitted securely. It is also in some food colorings, vanilla flavor, ice cream, and eye lubricant drops. Gmez-de la Fuente E, Rosado A, Gutirrez-Pascual M, Vicente FJ, Lpez-Estebaranz JL. Dermatology Made Easybook. Product formulations also change frequently. 8600 Rockville Pike If you have any concerns with your skin or its treatment, see a dermatologist for advice. A 52-year-old woman using topical minoxidil solution to treat her hair loss presented with a complaint of increased scaling and scalp pru-ritus. Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society's Allergen of the Year for 2018.