In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. Trials showed that spreading out dosing was more successful than lowering. This option has somewhat fewer risks than option 1, has a higher initial cost ($1,000 for the nebulizer mask), but a lower monthly cost- $20-$40/month. Summer-pasture-associated horses tend to be triggered by spring/summer allergens like grasses and trees, and classic horses tend to be triggered by barn dust and mold spores. 25. If you must give corticosteroids to an asthmatic horse, your veterinarian might prescribe them to be administered via an aerosol route through the nostril (rather than orally or via injection), which minimizes the amount that gets into the general circulation. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Cosgrove SB, Wren JA, Cleaver DM, et al. Acupuncture: It appears that some horses with Equine Asthma can benefit from acupuncture to help with breathing function. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. @vxf111 we were told the same thing for food allergiesthat they did not make serums fot them because they were not very effecttive and the the expectation was that the allergen be removed from the diet. Avoiding Allergies Six adult horses with a mean weight of 528 kg were . The drug is primarily used as a tranquilizer to calm anxious pets, especially dogs and horses, according to DailyMed. Weve been doing really well with every other day dosing. 24. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Allergies are generally managed based on the severity of clinical signs. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. Apoquel is a dog allergy medicine used to treat and control chronic manifestations of allergic and atopic dermatitis in dogs. APOQUEL may be administered with or without food. If your horses allergies are seasonal, talk to your veterinarian about steps you can take to stay ahead of them. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Oclacitinib should not be given in dogs younger than 12 months of age due to an increased risk for activating demodicosis, bacterial pneumonia, and other serious infections. Right now he is on an Aservo Inhaler but I dont see any improvement and he is getting real tired of the application process. Oclacitinib is well tolerated and, compared with classic allergy medications such as glucocorticoids and cyclosporine, equally effective in controlling pruritus. Simpson AC, Schissler JR, Rosychuk RAW, et al. Lopes NL, Campos DR, Machado MA, et al. Vet Dermatol 2019;30(1):17-e6. Oclacitinib, a Janus kinase inhibitor, has become an important drug in the management of allergic pruritus. 7. Administer it orally in the mouth of the or mix it in the dog food. holy crapola batman- just had to put my dog back on it (Hes usually on it April through Nov but with the weird weather we got away with waiting until July thankfully) and saw the price increase- yikes! However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. For this first stretch, thats not going to get me too far since I need the loading dose up front. I havent noticed any abnormal side effects. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. Vet Dermatol 2015;26(3):171-179, e35. Oclacitinib maleate is used twice daily for two weeks and then dropped to a maintenance dose of once daily. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. Because insects are omnipresent in the horses environment at least some portion of the year, IBH is particularly labor-intensive to manage. Gonzales AJ, Humphrey WR, Messamore JE, et al. We cannot be sure of accurate dosing when tablets are quartered, and thus this practice is not recommended. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label. Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. This site is intended for US animal healthcare professionals. 8. Several reports of successful use of oclacitinib to treat other diseases have been published. Apoquel doses are usually between .04-.06 milligrams per kilogram of body weight (mg/kg) . Transdermal applicator designed for easy handling and accurate dosing. Powered by Discourse, best viewed with JavaScript enabled. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol 2013;24:48-e12. test dose in your pet before long-term use, espe- cially in horses. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. BMC Vet Res 2019;15(1):137. The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. These are known as allergy shots. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . 2. on various factors. 2. Excitement rather than lethargy can occur occasionally, especially in cats. Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. Bursatti, Leeches) in Dogs, Cats and Horses. Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. Apoquel is not FDA approved to use twice daily longer than 14 days. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. Dosing Chart Warnings With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. These reports suggest the potential use of oclacitinib in other diseases; however, it cannot be stressed enough that the use of oclacitinib in these diseases is an off-label use. All rights reserved. More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. $ 78.30 - $ 245.00. Nobody wants to be itchy and constantly scratching. The bodys largest organ, the skin serves as the immune systems first protective barrier. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. This gives you the total number of milligrams for the dose for your horse. llergies can develop at any time, in any horse, and for virtually any reason. If she stays the way she is now, I will play with spacing it out furtherfirst with every 2 days. Unlike some other allergy. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. These might include antihistamines such as cetirizine, which you can buy over the counter as Zyrtec from any drug store or pharmacy, or hydroxyzine, which requires a veterinary prescription. Download Apoquel Information Sheet. and unfortunately grass and dust are the main culprits. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Webcast | Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. The efficacy and safety of oclacitinib have been assessed in various studies. not random, very relevant and helpful! The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Vet Dermatol 2016;27(Suppl 1):84 (abstract). actually treats degenerative joint disease (DJD), not just its clinical signs. They result in the production of antibodies that block the allergy-causing IgE from recognizing the allergen, thus preventing the associated symptoms.. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Also. While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. Apoquel tablets provide quick relief for itching and inflammation. 20. This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. So what else can we do for our Equine Asthma patients? This would be treatment with a systemic steroid (usually dexamethasone or prednisolone). May be used with other common medications. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? The purpose of Apoquel 16mg Tablets for dogs is to alleviate itching related to allergic dermatitis and address the signs of atopic dermatitis. For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. Log in to browse, order and prescribe from our compounded drugs formulary. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. She still has her mane this year- which is good! Apoquel is the brand name of oclacitinib, a dog medication designed to relieve itching associated with allergies in dogs, particularly canine atopic dermatitis. Thank you! If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control. This medication may be a very good option for minis, since the costs will be much lower. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is of a 3.6 mg tablet twice daily. Both can be very serious. Adding an update here in case its helpful for others. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Atopic dermatitis is often a complex disease that requires a multifaceted approach. Weve also been able to start rehabbing back into work. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. The downside is that it can cause laminitis and can suppress their immune system. Pet owners should visit ZoetisPetcare.com for product info, rewards and support. Vet Dermatol 2015;26:134 (abstract). Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. Adv Vet Dermatol 2017;8:192-198. Genome Biol 2004;5(12):253. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Option 4 is an oral tablet called Apoquel. Luckily most of her allergies appear to be insect-based and she responds very well to the serum for that. All product and company names are trademarks or registered trademarks of their respective holders. Gadeyne C, Little P, King VL, et al. Let's look at the differences between these two medications, as well as some other treatment options for your dog's allergies. Apoquel sorted the problem in a day but after doing some research after noticing her doing some chewing again Apoquel has some disturbing side effects as it suppresses the immune system. Minimum order 6 tablets per dosage. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Panteri A, Strehlau G, Helbig R, et al. Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. . Its anti-inflammatory and expectorant properties can soothe irritated lung tissues and help to expel mucus.Licorice root should not be fed to pregnant mares. Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov .