Before sharing your knowledge on this site, please read the following pages: 1. Course Hero uses AI to attempt to automatically extract content from documents to surface to you and others so you can study better, e.g., in search results, to enrich docs, and more. Biology, Living Organisms, embryology, Amphibian Eggs, Organizer, Nature and Action. On the other hand, different results are observed if the donor embryo used is in a late stage of gastrulation instead of an early stage of gastrulation. Because of this, the anterior portion is called the head organizer and the posterior part is designated as the trunk organizer. But the existence of both qualitative and quantitative differences in the chordamesoderm is the recent view on neural induction. Embryonic Induction. In fact, these proteins and their mRNAs are completely interchangeable! 5.23 indicates that the organizer is not a homogeneous system. A. gene mutationB. TOS4. capacity to produce a signal by the inducing. But opting out of some of these cookies may affect your browsing experience. The most remarkable finding of all was that the neural folds were built from recipient cells, not donor cells. Xenopus development (and probably that of animals in general) passes through three rather different (although often overlapping) phases: This page titled 14.4: The Organizer is shared under a CC BY 3.0 license and was authored, remixed, and/or curated by John W. Kimball via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request. To make it easier to follow the fate of the transplant, she used the embryo of one variety of newt as the donor and a second variety as the recipient. During gastrulation, the potencies of ectoderm become limited from general to specific one. In endogenous induction Endogenous inductors are undergoes self differentiation or self transformation. functioning p53 proteinC. From this experiment and others, it was known that the induction of the neural system is due to the underlying tissue, namely the chordamesoderm (presumptive notochord and somite mesoderm). The chordamesoderm is regarded as a two-dimensional sheet having a pair of gradients. Welcome to BiologyDiscussion! The medium is called the conditioned medium. If the invagination is prevented by treatment of the amphibian blastula with a solution of 0.35% sodium chloride solution as shown by Holtfreter in Exogastrulation Experiment, the dorsal ectoderm that normally becomes neural tube forms the ectodermal vesicle. The auditory vesicles, in turn, induce the surrounding mesenchyme to develop into the auditory capsule. Published on - 27/04/2020Embryonic Induction and Organizers Part-1course- B.Sc-part-1paper-IIunit-5 These organizers have been found in dorsal and ventral poles of GASTRULA embryos, including Spemann organizer in amphibians, and Hensen node in chicken and mouse. Therefore, the fates of presumptive nervous tissue or presumptive epidermis are not fixed at the early gastrula stage. The organizers of a embryonic cell are regions or groups of cells that can change their fate and develop a pattern of neighboring embryonic cells. Similarly, when a piece of the prospective epidermis was transplanted into the presumptive neural ectoderm, it developed into part of the neural tube. Share Your PPT File. There are diverse opinions regarding this aspect. The anterior portion used as graft into the blastocoel induces a head, while the posterior part as a graft produces a secondary trunk and tail. x\[oH~GyY"{7YCe-Qn\"Y; @;bXs\7fYM,Ww:i]}y/~Yne=TWO7 6}u/8 Perhaps the first major induction phenomenon occurs during the final stages of gastrulation of most animal embryos. During embryogenesis, the process of one group of cells influences or induces the direction of differentiation of the neighbouring group of cells is known as embryonic induction. endobj The hindbrain exerts inductive influence over the overlying ectoderm to form ear placode which becomes invaginated to form auditory vesicle. Embryonic induction In the early development of many tissues and organs of complex, multicellular organisms, the action of one group of cells on another that leads to the establishment of the developmental pathway in the responding tissue. endobj Because of the pigmentation difference between the species, it could be seen that much of the secondary axis is produced from host tissue. This differential action of the chordamesoderm indicates that the organizer is heterogeneous, but the origin and nature of differences between the different regions are difficult to interpret. In other words, one tissue gives the stimulus for the development of the other tissue subsequently. The transplantation experiment of Spemann and Mangold (1924) with the dorsal lip of the blastopore and the exogastrulation experiment of Holtfreter (1933) with amphibian embryo also suggest another phenomenon in embryonic differentiation. These experimental studies have revealed that the grey crescent material of the egg gives rise to the dorsal lip of the blastopore in early gastrula. <> This influence of one structure in the formation of another structure is called embryonic induction. Our mission is to provide an online platform to help students to share notes in Biology. Disclaimer Copyright, Share Your Knowledge (Our examples will include the wings, legs, and eyes of Drosophila. Wilhelm Roux (1888) first described the grey crescent in amphibian egg. Such endogenous inductions have been reported in mesenchymal cell of echinoidea. The diencephalon forms paired optic vesicles which make contact with the overlying head ectoderm. In other words, the transplant had altered the fate of the overlying cells (which normally would have ended up forming skin [epidermis] on the side of the animal) so that they produced a second head instead! A. mitosis B. meiosis I C. meiosis II D. interkinesis E. cytokinesis, Which event most accurately describes cytokinesis? 3 0 obj According to one, there are different inductors present in the chordamesoderm, each one is responsible for the expression of a specific part of-the nervous system. Embryonic induction describes the embryonic process in which one group of cells, the inducing tissue, directs the development of another group of cells, the responding tissue. % Spectrophotometric and electrophoretic analyses indicate that the inducing substance in the medium as the macromoleculespredominantly nucleo- proteins. Select all that apply. Its accumulation on the dorsal side of the embryo unleashes the activity of Nodal a member of the Transforming Growth Factor-beta (TGF-) family. Accessibility StatementFor more information contact us atinfo@libretexts.orgor check out our status page at https://status.libretexts.org. The vital dye method and other marking devices, such as carbon particle technique and radioactive labelling method have been applied to ascertain the fate of grey crescent during development. Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. The primary organizer determines the main features of axis formation and organization of the vertebrate embryo. The medium is filtered by millipore filter paper. In Drosophila, DPP is produced in the dorsal region of the embryo and SOG is produced in the ventral region. of a second group of cells. The development of amphibian neural plate has shown that the dorsal lip of the blastopore invaginates inside the embryo and induces the dorsal ectodermal layer to form the neural structure. But in the late stage, i.e., when the gastrula transforms into an embryo, the grey crescent materials become localised in the head endoderm of the primitive gut. We also use third-party cookies that help us analyze and understand how you use this website. This experiment demonstrates that the neural tissue of the secondary embryo is entirely formed from the tissues of the hostthus suggesting the fact that the dorsal lip of the blastopore is not only the controller of development but also acts as an instigator to induce the host tissue to differentiate. These cookies will be stored in your browser only with your consent. Spemann called the dorsal lip of the blastopore the primary organizer, because of its ability when transplanted, it initiates the development of a secondary embryo. The organizer has the ability for self-differentiation and organization. The inductive phenomena that occur in all the cases suggest beyond doubt that induction can occur without cell contact and inductive agent is chemical. By clicking Accept, you consent to the use of ALL the cookies. Several years after the discovery of the organizer action by Spemann and Mangold, a vivid interest arose in the chemical nature of the factor responsible for embryonic induction. 5.22 demonstrates the formation of a secondary head as a result of grafting the dorsal lip of the blastopore. cells produces a signal that determines the fate. Improper replication of DNA during synthesis E. faulty DNA repair, What association is correct? Introduction to Embryology: The aim of this note is to familiarize the reader with the basic facts and problems of the science of embryology. This is a question and answer forum for students, teachers and general visitors for exchanging articles, answers and notes. It also has the power to induce changes within the cell and to organize surrounding cells, including the induction and early organization of neural tube. Fig. The forebrain inductor is present in same concentration along the length of the archenteron roof while the mesoderm inductor is present at its highest concentration at the posterior end and gradually diminishes to zero at the anterior end. What do you mean by permeability of membrane? The axis induction occurred, where a secondary axis forms (Figure 3, B, C), having a gut, neural tube, notochord, and somites. Embryonic Induction Figure 8-15 The Spemann-Mangold primary organizer experiment. a Wnt protein (establishes the anterior-posterior axis in all bilaterians), BMP (establishes the dorsal-ventral axis in all bilaterians), Nodal (establishes the left-right axis in all bilaterians). In exogenous induction In this pattern of induction some external influence of cell or tissue impress on neighboring cell through the process The ectoderm forms a lens which invaginates to form lens vesicle. These organizer cells communicate with each other via a network of secreted signaling proteins, such as BONE MORPHOGENETIC PROTEINS and their antagonists (chordin and noggin). Give an example. The groups of cells which influence the responding cells are termed the inducing tissue. Draw a neatly labeled diagram of chloroplast found in leaf, and its role in photosynthesis? Under the influence of the Nieuwkoop center, this region is a distinct one before gastrulation. Embryonic induction is a process whereby a cell group causes another group of cells to differentiate to a particular developmental fate. Embryonic Induction Embryonic Induction 8.1. In normal amphibian development the dorsal ectoderm just above the dorsal lip of the blastopore becomes the neural structure. This experiment suggests to the contention that the protein part of the nucleoprotein is more effective inducing agent. Spemann and Mangold used the differently pigmented embryos of the genus Triturus, so they could identify host and donor tissues on the basis of color. Both of these physically bind to BMP-4 molecules in the extracellular space and thus prevent BMP-4 from binding to receptors on the surface of the overlying ectoderm cells. 5.14). The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. This cookie is set by GDPR Cookie Consent plugin. C.The metaphase plate is the beginning, Which event may lead to cancer? The experiments of Rund and Spemann have emphasised the vital role of grey crescent in amphibian development (see Fig. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". Now integral to the field of developmental biology, induction is the process by which the identity of certain cells influences the developmental fate of surrounding cells. And, in fact, the answer is no. An "organizer" is formally defined as a region, or group of cells in an embryo that can both induce (change the fate) and pattern (generate an organized set of structures) adjacent embryonic cells. This cookie is set by GDPR Cookie Consent plugin. online study material and solutions of animal science. Content Guidelines 2. !$)dt,___^("!DG_6/_D"RI&YdeD5Unq_ ?4364'y~p1:d#(YO)kYdD. Which types of bacteria are used in Bt-cotton? When a cell group is capable of differentiation without the intervention of other, cellsthe differentiation is called the independent differentiation. Explain with suitable example. Nodal induces these dorsal cells to begin expressing the proteins of Spemann's organizer. Induction of neural tube by the dorsal lip of blastopore material is the first inductive phenomenon in amphibian ontogenesis. The structure, which induces the formation of another structure, is called the inductor or organizer. However, once these gradients have sent certain cells along a particular path of gene expression, the stage is set for those cells to begin influencing nearby cells to become increasingly diversified. The development of eye relates a similar story. They preferred to call the primary organizer of Spemann as embryonic inductor. French researchers have reported (in the 24 July 2003 issue of Nature) their discovery of a tail "organizer", that is, a cluster of cells in the embryo that induces nearby cells to contribute to the formation of the tail. In other words, cell-intrinsic signals (established between a nucleus and the particular cytoplasmic environment that cleavage has placed it in) lay the foundation for cell-cell interactions to further guide the cells of the embryo to assume their proper position in the embryo and to differentiate into their final specialized form and function. The name "embryology" is somewhat misleading. The LibreTexts libraries arePowered by NICE CXone Expertand are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot. What is a trophic hormone? The term "embryo" denotes the [] diffusion of a signaling molecule out of one cell and into other cells in the vicinity; diffusion of a signaling molecule from one cell into an adjacent cell that then secretes the same molecule to diffuse to the next cell and so on (a "cell-relay" mechanism); extension of projections from the plasma membrane of one cell until they make, the transplanted tissue developed into a second notochord, these went on to form a second central nervous system (portions of brain and spinal cord) and eventually, If their action is blocked, the ectodermal cells are allowed to follow their. Your email address will not be published. Therefore, the graft influenced the surrounding cells to develop into certain organs. The result: a second tail. She cut out a piece of tissue from the gray crescent region of one newt gastrula and transplanted it into the ventral side of a second newt gastrula. Although their actions are similar, the distribution of these proteins in Drosophila differs from that in Xenopus (as well as in mammals and other vertebrates). When the differentiation of a group of cells depends upon another group of cells such a process is called the dependent differentiation. At, Chromosome duplication occurs for the beginning of which process? In amphibian embryos, the dorsal ectodermal cells in a Induction is the process by which one group of. They removed tiny clusters of cells from the ventral part of the blastula (a region roughly opposite where the Spemann-like organizer forms) and transplanted this into a region of the host embryo that would normally form flank. Absence of the inducing tissue results in lack of or improper development of the induced tissue. When the dorsal lip of the blastopore of an early T. taeniatus gastrula was removed, and then implanted into the region of an early T. cristatus gastrula fated to become ventral epidermis (belly skin), the dorsal lip tissue invaginated and self-differentiate into the notochord and other mesodermal structures that normally form from new embryo (Figure 3). One candidate after another has been put forward and then found not to be responsible. This blocked BMP-4 binding to the overlying ectoderm and thus changed the fate of those cells to forming a second central nervous system rather than skin. Soon I was to work on the Spemann organizer, the Holy Grail of vertebrate developmental biology. The fore-brain inductor can induce forebrain, while the forebrain inductor in conjunction with the mesoderm inductor develops both neural and mesodermal structures. 2 0 obj The cookie is used to store the user consent for the cookies in the category "Performance". (With Methods)| Industrial Microbiology, How is Cheese Made Step by Step: Principles, Production and Process, Enzyme Production and Purification: Extraction & Separation Methods | Industrial Microbiology, Fermentation of Olives: Process, Control, Problems, Abnormalities and Developments. However, their actions on overlying cells are the same as in Xenopus; that is, the SOG protein prevents the DPP protein from blocking the formation of the central nervous system. Occurrence of successive inductions indicates the presence of diverse quality of embryonic induction. Induction. Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. The dorsal lip region is called the chorda-mesoderm because it develops normally into mesoderm and notochord. The influence exercised by parts of the embryo, which causes groups of cells to proceed along a particular path of development, is called embryonic induction. spemann (1938) referred to the dorsal lip cells and their derivatives (notochord, prechordal mesoderm) as the organizer because (1) they induced the host's ventral tissues to change their fates to form a neural tube and dorsal mesodermal tissue (such as somites), and (2) they organized host and donor tissues into a secondary embryo with clear to receive and interpret the signal via a signal. After about one to three weeks, the ectoderm cells formed neural and pigment cells. But is the embryo fully patterned in the fertilized egg? The chordamesoderm of a neurula stage is used as the implanted material. 5.24 shows the quantitative distribution of the two inducing substances. Embryonic induction is considered to play an important role in the development of tissues and organs in most animal embryos, from the lower chordates to the higher vertebrates. Share Your PDF File As the implanted material contains no cellsthe question of surface interaction of cells at the inductive interface becomes impossible. But these, substances cannot fully imitate the action of normal inductor, because regional organisation of the brain fails to occur by these artificial chemical stimulants. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. Protein synthesis by the cells of the organizer requires transcription of the relevant genes (e.g., chordin). Various parts of an embryo can induce the formation of other structures. In the embryonic development of a zygote, gradients of mRNAs and proteins, deposited in the egg by the mother as she formed it, give rise to cells of diverse fates despite their identical genomes. The best answers are voted up and rise to the top. One of the distinguishing features of vertebrates is their tail, which extends out behind the anus. Ever since then, vigorous searches have been made to identify the molecules liberated by the organizer that induce overlying cells to become nerve tissue. Why do you think that carbohydrates are not digested in the stomach? Certain tissues, especially in very young embryos, apparently have the potential to direct the differentiation of adjacent cells. Now the question arises whether the protein moiety or RNA part of nucleo- proteins is more effective as inducing agent. Transplant experiments with avian Hensons Nodes also give a parallel secondary axis. Required fields are marked *. It involves the transfer of chemicals from the inducing to reacting tissues. After about 7-10 days, all the cells of the explant are eliminated leaving only the medium in which the explant was cultured. It is a piece of tissue corresponding to the upper dorsal blastopore lip of the amphibian embryo, consisting of presumptive mesoderm and endoderm. Lecture 11 Embryonic induction - Embryonic Induction Ebonia B. Seraspe UP Visayas Miagao, Iloilo Embryonic induction is considered to play an important, 1 out of 1 people found this document helpful. Similar experiments with epithelio-mesen-chymal interactions in the differentiation of kidney, pancreas, salivary gland, thyroid and thymus glands, etc., also suggest this transfilter phenomenon. Induction, the capacity of some cells to evoke a specific developmental response in others, is a widespread phenomenon in development. It is also referred to as the Spemann organizer. The neural differentiation in amphibian development has shown that the archenteron roof induces the overlying ectoderm to develop into neural structures. 4 0 obj It also has the power to induce changes within the cell and to organize surrounding cells, including the induction and early organization of neural tube. Answer Now and help others. It is difficult to imagine that the relatively simple gradients in the egg could account for all the complex migration and differentiation of cells during embryonic development. . This is done by gradients of mRNAs and proteins encoded by the mother's genes and placed in the egg by her. He transplanted a piece of presumptive neural ectoderm of one early gastrula embryo into the prospective epidermis region of another. The cookies is used to store the user consent for the cookies in the category "Necessary". Fig. The cookie is used to store the user consent for the cookies in the category "Other. Many chemical substances, like sterols, fatty acids, proteins, glycogen, synthetic carcinogenic agents and even silica particles and dead tissue can induce neural tissue formation. A small fragment of embryonic ectoderm, excised from early gastrula, was put in the conditioned medium. The brain having been induced, develops regional specificity under the influence of head endoderm and mesoderm. stream These two gradients are co-ordinated in such a way in the chordamesoderm that a perfect pattern is established. The role of BMP-4 is taken by a related protein encoded by the decapentaplegic gene (dpp) and the role of chordin is taken by a related protein called SOG encoded by the gene called short gastrulation. This implies both the. Therefore, these movements are referred to as morphogenetic Necessary cookies are absolutely essential for the website to function properly. The embryonic induction events described above result in the formation of the heart field, a region of embryonic tissue that has the potential to express cardiac differentiation genes and to develop into myocardium. The result in Drosophila is that its central nervous system forms on the ventral side of the embryo, not on the dorsal! After fertilization and formation of the gray crescent, they migrated into the gray crescent region (destined to become the organizer) where they were translated into Wnt protein. Successive inductions occur in the development of embryonic structures. This fact indicates that the cells of the dorsal lip of blastopore have certainly liberated the inducing substances directly into the culture medium which have caused neural induction. Rb protein phosphorylatingD. We also acknowledge previous National Science Foundation support under grant numbers 1246120, 1525057, and 1413739. This website includes study notes, research papers, essays, articles and other allied information submitted by visitors like YOU. An injection of the mRNAs for BMP-4 or chordin into the blastoderm of the Drosophila embryo can replace the function of DPP and SOG respectively, and conversely, injections of mRNA for DPP or SOG into the Xenopus embryo mimics the functions of BMP-4 and chordin respectively. Embryonic induction is a process whereby a cell group causes another group of cells to differentiate to a particular developmental fate. And, you may remember that one of the distinguishing traits of all arthropods (insects, crustaceans, arachnids) as well as many other invertebrates, such as the annelid worms, is a ventral nerve cord. This influence of one structure in the formation of another structure is called embryonic induction. Thus induction is caused in the absence of inducing cells. Two alternate possibilities can be suggested: Most of the experimental evidences on this line suggest the existence of chemical mediation between the inductor and induced structures. 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