1996 Jul 26;52(2):187-95. 1 -lactam antibiotics, including cephalosporins, are PBP inhibitors [, Layton A: The use of isotretinoin in acne. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Avoid life-threatening adverse drug events & improve clinical decision support. [, Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. VE TC. The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Acarbose. Download (52.7 KB) Clinical Trials Clinical Trials . J Clin Pharmacol. Improve clinical decision support with information on. U.S. Patent US5919931, issued September, 1986. Isosorbide mononitrate was shown to be significantly removed from the systemic circulation via hemodialysis. Arch Biochem Biophys. Pharmaceutical Utilization Management Program VA Inc. Moncada S, Palmer RM, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. [. Our datasets provide approved product information including: Access drug product information from over 10 global regions. MSDS. This information should not be interpreted without the help of a healthcare provider. Dinutuximab: The risk or severity of bleeding can be increased when Dextran is combined with Dinutuximab. 5,6 It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. 2000 Jan 21;275(3):1699-707. Isotretinoin is a retinoid used to treat severe recalcitrant acne. Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3--methoxyethyl ester 5-isopropyl ester, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate. 1984 Sep 15;33(18):2915-9. doi: 10.1016/0006-2952(84)90216-8. [, Talseth T, McNay JL, Haegele KD: Hypotensive effect of the hydralazine--acetone hydrazone in conscious rabbits: evidence for its back-conversion to hydralazine in vivo. Food increases exposure to hydralazine, though this may not be clinically significant. Generic Name Olanzapine DrugBank Accession Number DB00334 Background. Nimodipine is a calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. It has also been shown to be bound to the alpha-1 acid glycoprotein.18, Hepatic metabolism of doxazosin produces inactive O-demethylated and C-hydroxylated metabolites. 7,19 Traces of radiolabeled unchanged drug were found in the urine and about 5% of the administered drug Clin Cancer Res. Life Sci. Dinoprostone: The excretion of Dinoprostone can be decreased when combined with Cefotaxime. Improve clinical decision support with information on. J Pharmacol Exp Ther. NO activates soluble guanylyl cyclase in vascular endothelial cells, which increases the intracellular concentrations of cyclic GMP (cGMP). [. In a pharmacokinetic study using a 1 mg IV radiolabeled dose and a 2 mg oral dose, 63% of the ingested doxazosin was found to be excreted in the feces and about 9% of the dose was found to be excreted in the urine. Arthritis Rheum. J Neural Transm (Vienna). Pharm Res. Avoid life-threatening adverse drug events & improve clinical decision support. Avoid alcohol. This information should not be interpreted without the help of a healthcare provider. doi: 10.1093/cid/cit673. Isosorbide dinitrate: The risk or severity of methemoglobinemia can be increased when Nitroprusside is combined with Isosorbide dinitrate. J Cardiovasc Pharmacol. Ann Neurol. Clin Infect Dis. The metabolism of Abemaciclib can be decreased when combined with Hydralazine. [. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. The absence of an interaction does not necessarily mean no interactions exist. Auton Autacoid Pharmacol. 11 The peak response of amphetamine occurs 1-3 hours after oral administration and approximately 15 minutes after 1998 Aug 1;102(3):625-32. Hydralazine is an antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . Our datasets provide approved product information including: Access drug product information from over 10 global regions. Acetaminophen may decrease the excretion rate of Hydralazine which could result in a higher serum level. [, Bolattin M, Nandibewoor S, Joshi S, Dixit S, Chimatadar S: Interaction of Hydralazine with Human Serum Albumin and Effect of -Cyclodextrin on Binding: Insights from Spectroscopic and Molecular Docking Techniques Industrial & Engineering Chemistry Research. [, Pahuja A, Bashir J, Williamson EM, Barber N: Unresolved priapism secondary to tamsulosin. Clin Pharmacol Ther. 12 Indicated for the management of variant angina (Prinzmetal's angina). Arzneimittelforschung. Drug Metab Rev. Epub 2011 Jul 1. Acta Cardiol. Acemetacin may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. [, Melnik BC: Isotretinoin and FoxO1: A scientific hypothesis. 2008 Dec;20 Suppl 3:S33-43. [, Brodde OE, Kroemer HK: Drug-drug interactions of beta-adrenoceptor blockers. The metabolism of Acalabrutinib can be decreased when combined with Doxazosin. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 12 Indicated for use to improve exercise tolerance in patients with chronic stable angina. Easily compare up to 40 drugs with our drug interaction checker. J Pharm Sci. Isosulfan blue 7 The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Acetylsalicylic acid may decrease the antihypertensive activities of Nimodipine. Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). 11 Intravenous [, Kaye B, Cussans NJ, Faulkner JK, Stopher DA, Reid JL: The metabolism and kinetics of doxazosin in man, mouse, rat and dog. Isotretinoin may decrease the excretion rate of Abacavir which could result in a higher serum level. Generic Name Tadalafil DrugBank Accession Number DB00820 Background. 1986 Feb;75(2):146-9. doi: 10.1002/jps.2600750208. Naunyn Schmiedebergs Arch Pharmacol. Epub 2006 May 4. Indian J Anaesth. Pharmacotherapy. [, Dujic T, Zhou K, Donnelly LA, Tavendale R, Palmer CN, Pearson ER: Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Its use as a radioactive ligand for the enzyme. [, Joseph SS, Lynham JA, Colledge WH, Kaumann AJ: Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. The risk of these effects is particularly high when dose adjustments occur or there are long intervals between doxazosin doses. New studies suggest that telmisartan may also have PPAR agonistic properties that could potentially confer beneficial [, Tsukada M, Schroder M, Seltmann H, Orfanos CE, Zouboulis CC: High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intracellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes. K. S. Keshava Murthy, Gamini Weeratunga, Tianhao Zhou, Bhaskar Reddy Guntoori, "Process for the manufacture of intermediates suitable to make doxazosin, terazosin, prazosin, tiodazosin and related antihypertensive medicines." Circ Res. Easily compare up to 40 drugs with our drug interaction checker. It reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons. Ampicillin may increase the anticoagulant activities of Acenocoumarol. Drug Metab Dispos. In Rang and Dale's Pharmacology (7th ed., pp. The therapeutic efficacy of Nimodipine can be decreased when used in combination with Aceclofenac. Generic Name Sotalol DrugBank Accession Number DB00489 Background. doi: 10.1111/j.1365-2125.1986.tb02849.x. Isosorbide Mononitrate CR 60 mg 24 Hour tablet, Isosorbide Mononitrate CR 30 mg 24 Hour tablet. Acyclovir may decrease the excretion rate of Ampicillin which could result in a higher serum level. Generic Name Carvedilol DrugBank Accession Number DB01136 Background. J Clin Hypertens (Greenwich). In humans, nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Vitamin B12; Vitamin B12 complex; Vitamin B12 NOS; Pharmacology Indication. Avoid life-threatening adverse drug events & improve clinical decision support. Dermatoendocrinol. [, FDA Approved Drug Products: CARDURA (doxazosin mesylate) tablets [, FDA Approved Drug Products: CARDURA XL (doxazosin) extended release tablets [, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Murfreesboro Pharmaceutical Nursing Supply. Amphetamine is well absorbed in the gut and as it is a weak base hence the more basic the environment the more of the drug is found in a lipid-soluble form and the absorption through lipid-rich cell membranes is highly favored. http://www.chemspider.com/Chemical-Structure.4445539.html, https://www.sciencedirect.com/science/article/pii/S0927775716305817, https://www.rochecanada.com/content/dam/rochexx/roche-ca/products/ConsumerInformation/MonographsandPublicAdvisories/Accutane/Accutane_PM_E.pdf. [, Liu XQ, Ren YL, Qian ZY, Wang GJ: Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes. 3 Bacitracin was Br J Clin Pharmacol. 3 The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Label Taking tamsulosin with food increases the time to maximum Isosorbide: Isosorbide may increase the excretion rate of Nitroprusside which could result in a lower serum level and potentially a reduction in efficacy. (2012). 1995 Jan-Mar;15(1):13-25. Phase Status Purpose Conditions Count; 4: 2005 May-Jun;17(3):293-4. doi: 10.1038/sj.ijir.3901281. [, Stage TB, Brosen K, Christensen MM: A Comprehensive Review of Drug-Drug Interactions with Metformin. Avoid life-threatening adverse drug events & improve clinical decision support. Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker. Buy Now! 2007 May;21(5):538-41. doi: 10.1089/end.2006.0107. Neurobiology (Bp). 13 Ethambutol was first described in the literature in 1961. [, Mancuso C, Navarra P, Preziosi P: Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis. Dinoprostone: The excretion of Dinoprostone can be decreased when combined with Cefotaxime. 1973 Nov-Dec;14(6):970-7. doi: 10.1002/cpt1973146970. The pharmacological action is mediated by the active metabolite, nitric oxide, which is released when isosorbide mononitrate is metabolized.3 Nitric oxide works on both arteries and veins, but predominantly veins: by relaxing veins and reducing the central venous pressure, nitric oxide causes venous pooling and a decrease in the venous return to the heart, thus decreasing cardiac preload.7 In healthy subjects, the stroke volume is decreased and venous pooling can occur in the standing posture, leading to postural hypotension and dizziness.3, At therapeutic doses of isosorbide mononitrate, nitric oxide has a bigger effect on larger muscular arteries over small resistance arteries. 1994;26(3):485-505. doi: 10.3109/03602539408998315. 2018 Dec;15(12):1862-1869. doi: 10.1016/j.hrthm.2018.07.010. [, Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. Avoid life-threatening adverse drug events & improve clinical decision support. Ampicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level. The use of epinephrine or other arterial vasoconstrictors is not recommended.4, Drug created at June 13, 2005 13:24 / Updated at November 08, 2022 04:59. Isosulfan blue [, Wolpert C, Schimpf R, Giustetto C, Antzelevitch C, Cordeiro J, Dumaine R, Brugada R, Hong K, Bauersfeld U, Gaita F, Borggrefe M: Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. Nimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscle. This information should not be interpreted without the help of a healthcare provider. High-fat food increases drug absorption. The serum concentration of Isotretinoin can be increased when it is combined with Abametapir. InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3, N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide, Use our structured and evidence-based datasets to. Acetylsalicylic acid may decrease the excretion rate of Ampicillin which could result in a higher serum level. The therapeutic efficacy of Doxazosin can be decreased when used in combination with Acemetacin. [, FDA Approved Drug Products: Betapace (sotalol) tablets for oral use [, FDA Approved Drug Products: Sotalol hydrochloride for intravenous injection [, FDA Approved Drug Products: Sotylize (sotalol hydrochloride) solution for oral use [, Murfreesboro Pharmaceutical Nursing Supply, Lowe MD, Lynham JA, Grace AA, Kaumann AJ: Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. Ashok Kumar, Dharmendra Singh, Ganesh Devidas Mahale, Ragnesh Kumar Rana, Mahesh Kharade, "PROCESS FOR PREPARATION OF HIGHLY PURE ISOTRETINOIN." Epub 2014 Dec 15. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Mol Pharmacol. This action on blood vessels decreases systemic peripheral vascular resistance, reducing blood pressure, exerting minimal effects on the heart rate due to its receptor selectivity.5,10 Norepinephrine-activated alpha-1 receptors located on the prostate gland and bladder neck normally cause contraction of regional muscular tissue, obstructing urinary flow and contributing to the symptoms of benign prostatic hypertrophy. Epub 2007 Mar 26. [, Kpaeyeh JA Jr, Wharton JM: Sotalol. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Note: CaloMist Label, the nasal spray form, Label The maximum plasma concentration is 3.1-5.3ng/mL for a 0.4mg oral dose and 2.5-3.6ng/mL for a 0.8mg oral dose. The metabolism of Doxazosin can be decreased when combined with Abiraterone. New studies suggest that telmisartan may also have PPAR agonistic properties that could potentially confer beneficial Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. [, Roehrborn CG, Schwinn DA: Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. Epub 2013 Oct 2. Oral. Sotalol is a methanesulfonanilide developed in 1960. Acetylsalicylic acid may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level. Generic Name Bacitracin DrugBank Accession Number DB00626 Background. Drug Metab Pharmacokinet. The risk or severity of hypoglycemia can be increased when Sotalol is combined with Acarbose. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Improve clinical decision support with information on. 1996 Nov;13(11):1631-4. InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3, 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C, Use our structured and evidence-based datasets to. [, Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Arterial relaxation leads to reduced systemic vascular resistance and systolic blood (aortic) pressure, decreasing to decreased cardiac afterload.7,3 The direct dilator effect on coronary arteries opposes the coronary artery spasm in variant angina or angina pectoris.3 At larger doses, nitric oxide causes the resistance arteries and arterioles to dilate, reducing arterial pressure via coronary vasodilatation. 1982 Apr;6(4 Pt 2 Suppl):643-51. Label The area under the curve is 151-199ng/mL*hr for a 0.4mg oral dose and 440-557ng/mL*hr for a 0.8mg oral dose. The metabolism of Acalabrutinib can be decreased when combined with Hydralazine. Alcohol with isotretinoin can lead to inflammation of the liver. 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3--methoxyethyl ester 5-isopropyl ester Nimodipine may increase the vasodilatory activities of Isosorbide mononitrate. [, Valdes SO, Miyake CY, Niu MC, de la Uz CM, Asaki SY, Landstrom AP, Schneider AE, Rusin CG, Patel R, Lam WW, Kim JJ: Early experience with intravenous sotalol in children with and without congenital heart disease. Isosorbide mononitrate 2-glucuronide; Route of elimination. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. 1980 Oct;18(4):629-37. Card Electrophysiol Clin. 3 Bacitracin was [, Haegele KD, Skrdlant HB, Talseth T, McNay JL, Shepherd AM, Clementi WA: Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine. J Korean Neurosurg Soc. Isosorbide mononitrate: Amiloride may increase the excretion rate of Isosorbide mononitrate which could result in a lower serum level and potentially a reduction in efficacy. 2010 Mar;54(2):127-31. doi: 10.4103/0019-5049.63652. Generic Name Carvedilol DrugBank Accession Number DB01136 Background. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. [, Kim JH, Park IS, Park KB, Kang DH, Hwang SH: Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. 2011 Aug 18;2:e193. Xi An Lin (Changzhou Pharmaceutical Factory), sulfonamide, secondary alcohol, secondary amino compound, ethanolamines (, Potassium voltage-gated channel subfamily H member 2, C07AA Beta blocking agents, non-selective, C07BA Beta blocking agents, non-selective, and thiazides, C07B BETA BLOCKING AGENTS AND THIAZIDES, C07FX02 Sotalol and acetylsalicylic acid, C07FX Beta blocking agents, other combinations, C07F BETA BLOCKING AGENTS, OTHER COMBINATIONS, Beta Blocking Agents, Non-Selective, and Thiazides, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Heart Failure With Preserved Ejection Fraction (HFpEF), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-ITFT , negative, splash10-0udi-0090000000-b3dca1dbda7d2457ee97, splash10-00di-0090000000-a29ae691c7c3aac0cd25, splash10-00di-0090000000-3826232ebd5c11e1fb09, splash10-0uk9-0590000000-c1cd421f642943a3e40d, splash10-00di-0090000000-62e0058eee644436c974, splash10-00di-0090000000-1c2e1183f392f02dd2f3, splash10-00di-0900000000-467f723fa9c5b11ac3a0, splash10-0udi-0090000000-ec702c0822212cb2e764, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0a4i-0090000000-3fe820b16cdb741dfa3e, splash10-0ab9-0090000000-ba1b9c76db4e9239d8ff, splash10-0a4i-0090000000-9855a87a9a317eccb37e, splash10-03e9-0690000000-0c5b752605586d60828a, splash10-001i-0910000000-399c8ea4647bc5a24781, splash10-001i-0900000000-f44d2d18cd4dfd9b2756, splash10-053r-0900000000-422f178f83cadcda84d7, splash10-0ab9-0090000000-06e3079747baad9d6087, splash10-0a4i-0090000000-69df046b345e5e50d742, splash10-03e9-0690000000-94ba050da9e6a24f29b1, splash10-001i-0910000000-0ef0a4777ff5e99c8462, splash10-001i-0900000000-52c0f117b0c8ef4e0b76, splash10-053r-0900000000-ade6b1782a916acc1d7e, splash10-0a4i-0090000000-ef1bcb821ca9cd1627a8, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-0a4i-0090000000-75d846e48f9d41af615c, splash10-03e9-0790000000-610bf5222b1cb6f67b93, splash10-053r-0900000000-943fd2d5d938aa51d8d5, splash10-001i-0920000000-7400cd81d8ca70325a62, splash10-053r-0900000000-3b49e7b47aa69566cb3a, splash10-0a4i-0090000000-36ad35b8c37f5c9f4e91, splash10-0a4i-0090000000-1f8f59e1c29a48907b1d, splash10-0a4i-0390000000-7e44e05711b4dc722309. Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. [, Shroot B, Michel S: Pharmacology and chemistry of adapalene. Contribution to the hypertriglyceridemic action of retinoids. Easily compare up to 40 drugs with our drug interaction checker. The majority of hydralazine clearance is extrahepatic- 55% for rapid acetylators and 70% for slow acetylators.9 The average clearance in congestive heart failure patients is 1.770.48L/kg/h,9 while hypertensive patients have an average clearance of 42.78.9mL/min/kg.14, The oral LD50 in rats is 173-187mg/kg and the highest known dose an adult human has survived is 10g orally.19, Patients experiencing an overdose may present with hypotension, tachycardia, headache, flushing, myocardial ischemia, myocardial infarction, cardiac arrhythmia, and shock.19 Overdose can be treated through emptying the gastric contents and administering activated charcoal, though these treatments may cause further arrhythmias and shock.19 Supportive and symptomatic treatment should be administered.19, Drug created at May 16, 2007 20:38 / Updated at November 08, 2022 04:59. 6 Peak effect is observed about four hours after intrathecal administration. Elsevier. [, Ferry DG, Caplan NB, Cubeddu LX: Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein. 5,6 The dual action of carvedilol is Cefuroxime may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.